PAPA NONOate
Based on 2 publication(s) in Google Scholar
PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 146672-58-4
- Formula: C6H16N4O2
- Molecular Weight:176.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PAPA NONOate
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2]
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Dosage:100 μM
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Administration:Wounds received 100 μM PAPA NONOate in phosphate buffer
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Result:Increased the wound healing rate in test group.
Chemical Information
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CAS No. 146672-58-4
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Appearance Solid
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Molecular Weight 176.22
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Formula C6H16N4O2
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Color White to light yellow
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SMILES
NCCCN(CCC)N(O)N=O
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Structure Classification
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Initial Source
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Nano
Triple-Cascade Responsive Pneumatic Nanomotor Enhance Cancer Immunotherapy by Oncolytic Virus-Triggered Pyroptosis. [Abstract]2026 Mar 31;20(12):9784-9801. PMID: 41842752 -
Neurosci Bull
2025 Jun 28. PMID: 40580390
Solvent & Solubility
H2O : 50 mg/mL (283.74 mM; ultrasonic and warming and heat to 60°C)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Rössig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274(11):6823-6. [Content Brief]
[3]. Keefer LK, et al. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol. 1996;268:281-93. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.6747 mL | 28.3736 mL | 56.7472 mL | 141.8681 mL |
| 5 mM | 1.1349 mL | 5.6747 mL | 11.3494 mL | 28.3736 mL | |
| 10 mM | 0.5675 mL | 2.8374 mL | 5.6747 mL | 14.1868 mL | |
| 15 mM | 0.3783 mL | 1.8916 mL | 3.7831 mL | 9.4579 mL | |
| 20 mM | 0.2837 mL | 1.4187 mL | 2.8374 mL | 7.0934 mL | |
| 25 mM | 0.2270 mL | 1.1349 mL | 2.2699 mL | 5.6747 mL | |
| 30 mM | 0.1892 mL | 0.9458 mL | 1.8916 mL | 4.7289 mL | |
| 40 mM | 0.1419 mL | 0.7093 mL | 1.4187 mL | 3.5467 mL | |
| 50 mM | 0.1135 mL | 0.5675 mL | 1.1349 mL | 2.8374 mL | |
| 60 mM | 0.0946 mL | 0.4729 mL | 0.9458 mL | 2.3645 mL | |
| 80 mM | 0.0709 mL | 0.3547 mL | 0.7093 mL | 1.7734 mL | |
| 100 mM | 0.0567 mL | 0.2837 mL | 0.5675 mL | 1.4187 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PAPA NONOate Related Classifications
HY-134636 Related Classifications
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