2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PAT-078

PAT-078 is a type II autotaxin (ATX) inhibitor. PAT-078 mainly occupies the hydrophobic pocket of ATX, blocks the bottleneck region between the hydrophobic channel and the catalytic site, and does not interact with the zinc ion at the catalytic site.

For research use only. We do not sell to patients.

PAT-078

PAT-078 Chemical Structure

CAS No. : 1682644-84-3

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PAT-078 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

PAT-078 is a type II autotaxin (ATX) inhibitor. PAT-078 mainly occupies the hydrophobic pocket of ATX, blocks the bottleneck region between the hydrophobic channel and the catalytic site, and does not interact with the zinc ion at the catalytic site[1].

In Vitro

PAT-078 is a type II human ATX inhibitor that occupies the hydrophobic pocket of the enzyme and induces pocket remodeling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PAT-078 Related Antibodies
Molecular Weight

430.86

Formula

C25H16ClFN2O2
CAS No.
SMILES

C(=C(\C#N)/C1=CC=C(C(O)=O)C=C1)\C=2C=3C(N(CC4=CC=C(F)C=C4)C2)=CC(Cl)=CC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PAT-078 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAT-0781682644-84-3PAT078PAT 078Phosphodiesterase (PDE)Autotaxinhydrophobic channelhydrophobic pocketcatalytic sitehuman ATX inhibitorATX/ENPP-2zinc ionsType II inhibitorInhibitorinhibitorinhibit

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