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Arazine (Synonyms: N-Acetyl-S-farnesyl-L-cysteine)

Cat. No.: HY-133021
Handling Instructions

Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.

For research use only. We do not sell to patients.

Arazine Chemical Structure

Arazine Chemical Structure

CAS No. : 135304-07-3

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5 mg (27.2 mM * 500  μL in Methyl Acetate) USD 280 In-stock
Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description

Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site[1].

In Vitro

Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell[1].
Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell[1].

In Vivo

Arazine (AFC) (2,000 μg/20 μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12 μg/20 μl[1].

Animal Model: TPA-induced ear acute inflammation in mouse[1]
Dosage: 2000 μg/20 μl
Administration: 2000 μg/20 μl; Applied on ear
Result: Inhibited ear edema, as measured by ear weight.
Molecular Weight

367.55

Formula

C₂₀H₃₃NO₃S

CAS No.

135304-07-3

SMILES

O=C(O)[[email protected]](CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)NC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ArazineN-Acetyl-S-farnesyl-L-cysteineOtherssubstratecell-permeable modulatorInhibitorinhibitorinhibit

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Arazine
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