Pentiapine

Two hundred and fifty-seven male mice are used in this study. Animals are divided into 19 groups (n=8). The first group receives physiological saline, the second receives 40 mg/kg of morphine and the other eight groups receive 0.5, 1, 2, 4, 8, 16, 24 or 32 mg/kg of Pentiapine, respectively. The remaining groups receive an injection of morphine and 30 min afterwards, an injection of physiological saline, 0.5, 1, 2, 4, 8, 16, 24 or 32 mg/kg of Pentiapine, respectively. In the groups receiving only one injection, animals are placed onto the sensory plates for a period of 90 min immediately after treatment. The computer registers the activity each 15 min. In the groups receiving two injections, animals are placed onto the sensory plates immediately after the first injection for a period of 30 min then after the second injection the motor activity is registered at 15, 30, 45 and 60 min^[1].

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