BMI1
Bmi-1; B cell-specific Moloney murine leukemia virus integration site 1
B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), a component of the polycomb repressive complex 1 (PRC1), is recognized as a polycomb protein that prevents premature senescence and maintains the self-renewal capacity of stem cells.
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BMI1 Related Products (11)
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PTC-209
0 ImagesPTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment. -
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MS147
0 ImagesCat. No.: HY-160924Purity: 98.31%MS147 is a VHL-based PROTAC degrader of BMI1 and RING1B (polycomb repressive complex 1 core components). MS147 directly binds EED and VHL E3 ligase, recruiting the ligase to the EED-BMI1/RING1B complex to induce time-dependent, ubiquitination-mediated degradation of BMI1 and RING1B. MS147 reduces histone H2A Lys119 mono-ubiquitination without altering histone H3 Lys27 tri-methylation and inhibits cancer cells proliferation. MS147 can be used for the research of cancer, such as chronic myelogenous leukemia and b-cell lymphoma. -
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PTC-209 hydrobromide
0 ImagesPTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment. -
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SH498
0 ImagesCat. No.: HY-143658CAS No.: 2125724-38-9SH498, a novel Bmi-1-mediated antitumor agent, shows potent antiproliferative activity. -
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APD-94
0 ImagesCat. No.: HY-172617CAS No.: 877810-03-2APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study. -
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QW24
0 ImagesCat. No.: HY-143655CAS No.: 2416312-06-4QW24 exerts potent anti-tumor activity by down-regulating BMI-1 and is used as an effective therapeutic agent for clinical colorectal cancer research. -
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1,6,7-Trihydroxyxanthone
0 ImagesCat. No.: HY-N0992CAS No.: 25577-04-21,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16. -
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PTC-028 (Standard)
0 ImagesCat. No.: HY-103696RCAS No.: 1782970-28-8PTC-028 (Standard) is the analytical standard of PTC-028 (HY-103696). This product is intended for research and analytical applications. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis. -
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- BMI1/RING1B ligand-1
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