877810-03-2
877810-03-2
Chemical Structure
APD-94
- CAS No.: 877810-03-2
- Formula:C18H17N3O4
- Molecular Weight:339.35
SMILES: COC1=CC(O)=C(C2=NC(N)=NC=C2OC3=CC(OC)=CC=C3)C=C1
Biological Activity: APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study[1].
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APD-94 | APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study. | |||||||||||||||||||||
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