1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease

Beclabuvir (Synonyms: BMS-791325)

Cat. No.: HY-12429 Purity: 99.81%
Handling Instructions

Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. 

For research use only. We do not sell to patients.

Beclabuvir Chemical Structure

Beclabuvir Chemical Structure

CAS No. : 958002-33-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 610 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 1320 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1920 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 2880 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. 

IC50 & Target

IC50: < 28 nM (NS5B protein)

In Vitro

Beclabuvir demonstrates additive or synergistic antiviral activity with pegIFN/RBV and in 2- or 3-drug combinations with a range of DAAs, such as HCV NS3 protease inhibitors, NS5A inhibitors' and/or nucleoside NS5B inhibitors[2].

In Vivo

The combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1, which is the most common genotype worldwide[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (45.47 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5155 mL 7.5776 mL 15.1552 mL
5 mM 0.3031 mL 1.5155 mL 3.0310 mL
10 mM 0.1516 mL 0.7578 mL 1.5155 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

659.84

Formula

C₃₆H₄₅N₅O₅S

CAS No.

958002-33-0

SMILES

O=C(N1C2CCC1CN(C)C2)[[email protected]@]3(CN4C5=C(C6CCCCC6)C7=CC=C(C(NS(N(C)C)(=O)=O)=O)C=C47)[[email protected]](C8=CC(OC)=CC=C85)C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Beclabuvir
Cat. No.:
HY-12429
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Beclabuvir

Cat. No.: HY-12429