d-T101 peptide
d-T101 peptide, a human hormone-peptide, is a T1/ST2 receptor ligand. d-T101 peptide binds to the T1/ST2 receptor and activates caspases 8, 9 and 3 mediated apoptosis, together with activation of JNKinase and p38 MAPKinase. d-T101 peptide also changes Golgi structural with function loss and downregulation of the endoplasmic reticulum (ER) stress repair mechanism. d-T101 peptide has immunostimulatory and anticancer activity, selectively induces apoptosis in proliferating cancer cells and increases IL-2 and IFN-γ expression as well as the recruitment of NK cells and M1 macrophages to the tumor site.
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- No. CAS: 2120397-85-3
- Fòrmula: C96H129N21O20
- Peso molecular:1897.18
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Caspase-8 |
Caspase-9 |
Caspase-3 |
IL-2 |
Chemical Information
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No. CAS 2120397-85-3
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Peso molecular 1897.18
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Fòrmula C96H129N21O20
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Sequence
d(Trp-Trp-Thr-Phe-Phe-Leu-Pro-Ser-Thr-Leu-Trp-Glu-Arg-Lys)
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Sequence Shortening
d(WWTFFLPSTLWERK)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Sandler U, et al. NEROFE--a novel human hormone-peptide with anti-cancer activity. J Exp Ther Oncol. 2010;8(4):327-39. [Content Brief]
[2]. Ohana J, et al. dTCApFs, a derivative of a novel human hormone peptide, induces apoptosis in cancer cells through a mechanism involving loss of Golgi function. Mol Clin Oncol. 2017 Dec;7(6):991-999. [Content Brief]
[3]. Ohana J, et al. Transformation of immunosuppressive mtKRAS tumors into immunostimulatory tumors by Nerofe and Doxorubicin. Oncotarget. 2023 Jul 1;14:688-699. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
d-T101 peptide Related Classifications
HY-P11298 Related Classifications
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