Search Result

Results for "

Trypanosoma+brucei

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) AMPK (1) Antibiotic (1) Apoptosis (3) Aurora Kinase (1) Autophagy (4) Bacterial (2) Cathepsin (2) Clathrin (1) Cytochrome P450 (2) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (3) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (4) Fluorescent Dye (1) Fungal (3) IMPDH (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (2) PAK (1) Paraptosis (1) Parasite (45) Phosphodiesterase (PDE) (3) Phospholipase (2) PKA (1) Proteasome (1) Reference Standards (2) Ser/Thr Protease (1) STAT (3)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (48) Inflammation/Immunology (8) Metabolic Disease (1)

By Targets:

Adenosine Kinase (1)

AMPK (1)

Antibiotic (1)

Apoptosis (3)

Aurora Kinase (1)

Autophagy (4)

Bacterial (2)

Cathepsin (2)

Clathrin (1)

Cytochrome P450 (2)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (3)

Drug Intermediate (1)

Drug Metabolite (1)

Endogenous Metabolite (4)

Fluorescent Dye (1)

Fungal (3)

IMPDH (1)

Influenza Virus (1)

Isotope-Labeled Compounds (1)

Mitochondrial Metabolism (2)

PAK (1)

Paraptosis (1)

Parasite (45)

Phosphodiesterase (PDE) (3)

Phospholipase (2)

PKA (1)

Proteasome (1)

Reference Standards (2)

Ser/Thr Protease (1)

STAT (3)

By Research Areas:

Cancer (11)

Cardiovascular Disease (1)

Infection (48)

Inflammation/Immunology (8)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125731

Glycodeoxycholic acid 3 Publications Verification	Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-12054

Hesperadin Maximum Cited Publications 12 Publications Verification	Aurora Kinase Autophagy Influenza Virus Parasite	Cancer
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC₅₀ of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral .

HY-103056

DDD85646 1 Publications Verification IMP-366	DNA/RNA Synthesis Parasite	Infection
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .

HY-128170

Ebsulfur	Parasite	Infection
Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC₅₀ values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis .

HY-N7266

Obtusifoliol 1 Publications Verification	Cytochrome P450 Parasite	Infection Cancer
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively .

HY-153021

NMT-IN-1	Parasite	Infection
NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC₅₀ of 31 μM against TbNMT and an IC₅₀ of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .

HY-101015A

OBAA	Phospholipase Apoptosis	Inflammation/Immunology
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 nM. OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei with an IC₅₀ of 0.4 μM .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection .

HY-125731R

Glycodeoxycholic Acid (Standard)	Reference Standards Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-111759

Jaspamycin 1 Publications Verification 7-CN-7-C-Ino	PKA Parasite	Infection
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC₅₀ of 6.5 nM and K_d of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity .

HY-108938

SDZ285428	Cytochrome P450 Fungal Parasite	Infection
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .

HY-N6674

Diazepinomicin ECO-4601; TLN-4601; BU 4664L	Apoptosis Bacterial Cathepsin Parasite Endogenous Metabolite	Infection Inflammation/Immunology Cancer
Diazepinomicin (ECO-4601) is an anticancer and antibacterial agent. Diazepinomicin can be produced by a Micromonospora strain. Diazepinomicin induces Apoptosis. Diazepinomicin inhibits the proteases Rhodesain and Cathepsin L at an IC₅₀ of 70-90 μM. Diazepinomicin possesses anti-inflammatory and anti-tumor activity. Diazepinomicin has demonstrated activity against hepatocellular carcinoma. Diazepinomicin shows antiparasitic activity against trypomastigote forms of Trypanosoma brucei with an IC₅₀ of 13.5 μM. Diazepinomicin exhibits moderate antibacterial activity against specific Gram-positive bacteria, with an MIC of approximately 32 μg/mL .

HY-162066

DNDI-6174	Parasite	Infection
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis .

HY-155655

JC-229	Parasite	Infection
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

HY-135562

Ascofuranone	Parasite Antibiotic	Infection Cancer
Ascofuranone is an orally active inhibitor of Trypanosoma brucei brucei (TAO) with a K_i value of 2.38 nM. Ascofuranone inhibits IGF-1-induced cancer cell migration, invasion, motility and actin cytoskeleton formation, and exerts anti-tumor effects. Ascofuranone can be used in research related to tumor metastasis, African trypanosomiasis, bacterial infections, lung cancer and hepatocellular carcinoma .

HY-179690

Antiparasitic agent-30	Parasite Adenosine Kinase	Infection
Antiparasitic agent-30 is a potent adenosine kinase TbrAK modulator and antitrypanosomal agent. Antiparasitic agent-30 exhibits significant inhibitory activity against Trypanosoma brucei rhodesiense, while enhancing the activity of recombinant TbrAK(EC₅₀=38 nM, K_a=75 nM-497 nM). Antiparasitic agent-30 exerts its pharmacological effects by eliminating intrinsic substrate inhibition and hyperactivating TbrAK in Trypanosoma brucei rhodesiense. Antiparasitic agent-30 serves as a valuable tool molecule for studying acute African human trypanosomiasis (sleeping sickness) .

HY-W973644

LY-266500	Mitochondrial Metabolism Parasite	Infection
LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei (IC₅₀ =0.6 μM) and Leishmania donovani (IC₅₀ =2.86 μM). LY-266500 can be used for research on parasitic infections .

HY-W391625

(Rac)-Dehydrocostus Lactone (Rac)-Epiligulyl oxide	Fungal	Cancer
(Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .

HY-101015

(2E)-OBAA	Phospholipase Apoptosis	Inflammation/Immunology
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC₅₀ of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei, with an IC₅₀ of 0.4 μM .

HY-16121

CAA-0225	Cathepsin	Others
CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC₅₀ value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites ^[1][2][3].

HY-136200

Antitrypanosomal agent 2	Parasite	Infection
Antitrypanosomal agent 2 is a potent and selective trypanosoma brucei* inhibitor* .

HY-119938

Tuberculosis inhibitor 1	Bacterial	Infection
Tuberculosis inhibitor 1 is a potent and non-cytotoxic *trypanosoma brucei* growth inhibitor with an EC₅₀ of 5 nM .

HY-N3247

Monomethyl kolavate	Parasite	Others
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

HY-118580

RO-09-4609	Fungal Parasite	Infection
RO-09-4609 exhibits antimicrobial activity, that inhibits Candida albicans, Trypanosoma brucei and Plasmodium vivax through inhibition of N-myristoyl transferase .

HY-168538

Antitrypanosomal agent 21	Paraptosis	Infection
Antitrypanosomal agent 21 (Compound C-1) is a *trypanosoma brucei* inhibitor. Antitrypanosomal agent 21 decreases the level of D6XM23 in parasite lysates .

HY-125632

Ro 19-9638	Parasite	Infection
Ro 19-9638 is the major metabolite of Ro 15-0216. Ro 19-9638 exhibits antiparasitic efficacy against Trypanosoma brucei rhodesiense with an IC₅₀ of 0.0341 µg/mL .

HY-162656

DHFR-IN-19	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with K_i of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC₅₀ of 14.5 μM .

HY-144296

Purine phosphoribosyltransferase-IN-2	Parasite	Infection
Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with K_is of 30, 20 and 2 nM, respectively .

HY-157028

Antiparasitic agent-19	Others	Infection
Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .

HY-172297

Pyrazole N-Desmethyl sildenafil	Phosphodiesterase (PDE) Parasite	Infection Cardiovascular Disease Cancer
Pyrazole N-Desmethyl sildenafil (Compound 10) is an analog of Sildenafil (HY-15025). Pyrazole N-Desmethyl sildenafil shows 16% inhibition on Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) with 100 µM .

HY-W653999

Glycodeoxycholic acid-d5	Isotope-Labeled Compounds Endogenous Metabolite STAT Autophagy	Inflammation/Immunology
Glycodeoxycholic acid-d₅ is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-125084

NEU617	Parasite	Infection
NEU617 is an anti-parasite agent. NEU617 inhibits the proliferation for the HAT (human African trypanosomiasis) pathogen (EC₅₀: 42 nM for Trypanosoma brucei, 1.8 μM for T. cruzi). NEU617 is a derivative of Lapatinib (HY-50898) .

HY-147933

Antitrypanosomal agent 8	Parasite	Infection
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against *Trypanosoma brucei* with an IC₅₀ value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC₅₀=80.95 μM) .

HY-155207

Antileishmanial agent-23	Parasite	Infection
Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC₅₀ of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei .

HY-144294

Purine phosphoribosyltransferase-IN-1	Parasite	Infection
Purine phosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with K_i values of 50, 20, and 2 nM, respectively .

HY-W540326

Norbornane	Drug Intermediate	Infection Cancer
Norbornane is a component of the essential oil extracted from the rhizomes of Cyperus rotundus from Morocco. Active derivatives of Norbornane are fused heterocyclic compounds with in vitro anti-tumor and anti-Trypanosoma brucei activities. Norbornane and its derivatives can be used in research related to cancers such as leukemia and African trypanosomiasis .

HY-116045

PDEB1-IN-1	Parasite	Cancer
PDEB1-IN-1 (Compound 12b) is the derivative of Cilomilast (HY-10790), and serves as an inhibitor for TryPanosoma Brucei PDEB1 (TbrPDEB1) with an IC₅₀ of 0.95 μM. PDEB1-IN-1 inhibits the proliferation of T. Brucei with an EC₅₀ of 26 μM .

HY-147940

TbPTR1 inhibitor 1	Parasite	Infection
TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC₅₀<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC₅₀=0.66 μM) .

HY-170363

Proteasome-IN-6	Proteasome Parasite	Infection
Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC₅₀s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model .

HY-175305

DMU759	Parasite	Infection
DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research .

HY-147549

Antitrypanosomal agent 6	Parasite	Infection
Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against *Trypanosoma brucei* (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .

HY-147550

Antitrypanosomal agent 7	Parasite	Infection
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against *Trypanosoma brucei* (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .

HY-N16437

Panowamycin A	Parasite	Infection
Panowamycin A is an isochroman compound that can be produced by Streptomyces sp. K07-0010. Panowamycin A exhibits antitrypanosomal activity against the Trypanosoma brucei brucei GUTat 3.1 strain (IC₅₀: 0.40 μg/mL). Panowamycin A shows weak cytotoxicity towards human fetal lung fibroblast MRC-5 cells (IC₅₀: 2.95 μg/mL). Panowamycin A can be used for research in the field of antitrypanosomal studies .

HY-126250

NPD-1335	Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology
NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death . NPD-1335 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-146049

Antitrypanosomal agent 4	Parasite	Infection
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC₅₀s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-176253

Antitrypanosomal agent 26	Parasite	Infection
Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC₅₀ value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis .

HY-175517

PEX5-PEX14 PPI-IN-3	Parasite	Infection
PEX5-PEX14 PPI-IN-3 (Compound 7) is an inhibitor of the PEX5-PEX14 protein-protein interaction (PPI) with an EC₅₀ of 95 μM. PEX5-PEX14 PPI-IN-3 has an EC₅₀ of 7.2 μM against Trypanosoma brucei (T. brucei). PEX5-PEX14 PPI-IN-3 exhibits low cytotoxicity towards HepG2 cells and possesses antiparasitic activity .

HY-178064

Antiparasitic agent-29	Parasite Mitochondrial Metabolism	Infection
Antiparasitic agent-29 (Compound 5) is a Trypanosome alternative oxidase (TAO) inhibitor with an IC₅₀ of 1.3 nM in Trypanosoma brucei. Antiparasitic agent-29 has a broad-spectrum antiparasitic activity against Trypanosoma and Leishmania spp. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting its energy metabolism and has potent membrane-perturbing activity with no cross-resistance. Antiparasitic agent-29 shows low ecotoxicity in zebrafish and Daphnia magna models. Antiparasitic agent-29 can be used for parasitic diseases like surra and dourine research .

HY-175979

HAT-IN-9	Parasite	Infection
HAT-IN-9 (Compound 3F) is a selective proliferation inhibitor targeting Trypanosoma brucei. HAT-IN-9 inhibits the proliferation and division of Trypanosoma brucei. HAT-IN-9 is promising for research of African trypanosomiasis (HAT, i.e., sleeping sickness) .

HY-118606

LDN-0044878	PAK Parasite	Infection Cancer
LDN-0044878 is a PAK3 inhibitor. LDN-0044878 inhibits the proliferation or induces the death of p53-deficient cells. LDN-0044878 exhibits moderate trypanocidal activity against Trypanosoma brucei, but does not directly inhibit the core target Rhodesain. LDN-0044878 can be used in studies related to cervical adenocarcinoma and Trypanosoma brucei infection.

Cat. No.	Product Name	Target	Research Area

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei .

Cat. No.	Product Name	Category	Target	Chemical Structure