1. Metabolic Enzyme/Protease
    Anti-infection
  2. Phosphodiesterase (PDE)
    Parasite
  3. NPD-1335

NPD-1335 

Cat. No.: HY-126250
Handling Instructions

NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death.

For research use only. We do not sell to patients.

NPD-1335 Chemical Structure

NPD-1335 Chemical Structure

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Description

NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1].

IC50 & Target

pKi: 6.9 (TbrPDEB1); pIC50: 6.2 (T. brucei) (NPD-1335)[1]

Molecular Weight

455.55

Formula

C₂₈H₂₉N₃O₃

SMILES

O=C(NCC1=CC=CC=C1)C#CC2=CC(C3=NN(C(C)C)C([[email protected]@]4([H])CC=CC[[email protected]@]34[H])=O)=CC=C2OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
NPD-1335
Cat. No.:
HY-126250
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