2376326-31-5
Chemical Structure
NPD-1335
- CAS No.: 2376326-31-5
- Formula:C28H29N3O3
- Molecular Weight:455.55
IUPAC Name: N-benzyl-3-(5-((4aS,8aR)-3-isopropyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2-methoxyphenyl)propiolamide
InChIKey: CNKULZYKNGMIIR-RPWUZVMVSA-N
SMILES: O=C(NCC1=CC=CC=C1)C#CC2=CC(C3=NN(C(C)C)C([C@@]4([H])CC=CC[C@@]34[H])=O)=CC=C2OC
Biological Activity: NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1]. NPD-1335 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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NPD-1335 | 98.92% | NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death. NPD-1335 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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