Antitrypanosomal agent 4
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC50s of 1.2 μM and 70 nM, respectively. Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2456427-48-6
- Formula: C18H14ClN3O5S
- Molecular Weight:419.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
>125 μM
Compound: 19
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 32652409] |
| THP-1 | CC50 |
>100 μM
Compound: 19
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Cytotoxicity against human THP-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 32652409] |
Chemical Information
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CAS No. 2456427-48-6
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Molecular Weight 419.84
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Formula C18H14ClN3O5S
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SMILES
OCCC#CC1=CC(Cl)=CN2C1=NC(CS(=O)(C3=CC=CC=C3)=O)=C2[N+]([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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