TbPTR1 inhibitor 1
TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM).
For research use only. We do not sell to patients.
- CAS No.: 2499713-65-2
- Formula: C22H21N7O
- Molecular Weight:399.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
IC50: <0.1 nM (TbPTR1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Macrophage | CC50 |
25 μM
Compound: 5d
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Cytotoxicity against human THP-1 derived macrophages by colorimetric MTT assay
Cytotoxicity against human THP-1 derived macrophages by colorimetric MTT assay
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[PMID: 35675511] |
Chemical Information
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CAS No. 2499713-65-2
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Molecular Weight 399.45
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Formula C22H21N7O
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SMILES
O=C(C1=CC=C(N(CC)CC2=CN=C(N=C(N)N=C3N)C3=N2)C=C1)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TbPTR1 inhibitor 1 Related Classifications
HY-147940 Related Classifications
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