2499713-65-2
2499713-65-2
Chemical Structure
TbPTR1 inhibitor 1
- CAS. Nr.: 2499713-65-2
- Formula:C22H21N7O
- Molecular Weight:399.45
IUPAC Name: (4-(((2,4-diaminopteridin-6-yl)methyl)(ethyl)amino)phenyl)(phenyl)methanone
InChIKey: ASBJYAZYFSRQAB-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(N(CC)CC2=CN=C(N=C(N)N=C3N)C3=N2)C=C1)C4=CC=CC=C4
Biological Activity: TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM)[1].
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TbPTR1 inhibitor 1 | TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM). | |||||||||||||||||||||
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