OBAA
Based on 1 Customer Validation
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM.
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- Pureté: 99.31%
- CAS No.: 134531-42-3
- Formule: C28H44O3
- Masse moléculaire:428.65
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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PLA2 70 nM (IC50) |
OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells had disintegrated into apoptotic bodies[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 134531-42-3
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Appearance Solid
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Masse moléculaire 428.65
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Formule C28H44O3
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Color Off-white to light yellow
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SMILES
O=C(O)/C=C/C(C1=CC=C(CCCCCCCCCCCCCCCCCC)C=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 25 mg/mL (58.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. J Y Miao, et al. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J Biochem. 1997 Mar;121(3):612-8. [Content Brief]
[2]. J Eintracht, et al. Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. Biochem J. 1998 Dec 15;336 ( Pt 3)(Pt 3):659-66. [Content Brief]
[3]. T Köhler, et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. Biochem Pharmacol. 1992 Aug 18;44(4):805-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3329 mL | 11.6645 mL | 23.3291 mL | 58.3226 mL |
| 5 mM | 0.4666 mL | 2.3329 mL | 4.6658 mL | 11.6645 mL | |
| 10 mM | 0.2333 mL | 1.1665 mL | 2.3329 mL | 5.8323 mL | |
| 15 mM | 0.1555 mL | 0.7776 mL | 1.5553 mL | 3.8882 mL | |
| 20 mM | 0.1166 mL | 0.5832 mL | 1.1665 mL | 2.9161 mL | |
| 25 mM | 0.0933 mL | 0.4666 mL | 0.9332 mL | 2.3329 mL | |
| 30 mM | 0.0778 mL | 0.3888 mL | 0.7776 mL | 1.9441 mL | |
| 40 mM | 0.0583 mL | 0.2916 mL | 0.5832 mL | 1.4581 mL | |
| 50 mM | 0.0467 mL | 0.2333 mL | 0.4666 mL | 1.1665 mL |
OBAA Related Classifications
HY-101015A Related Classifications
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