2. Metabolic Enzyme/Protease Apoptosis
  3. Phospholipase Apoptosis
  4. OBAA

OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM.

For research use only. We do not sell to patients.

OBAA Chemical Structure

OBAA Chemical Structure

CAS No. : 134531-42-3

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Based on 1 publication(s) in Google Scholar

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Description

OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3].

IC50 & Target[3]

PLA2

70 nM (IC50)

In Vitro

OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells had disintegrated into apoptotic bodies[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OBAA Related Antibodies
In Vivo

The immunologically induced bronchospasm in guinea pigs is significantly and dose-dependently inhibited by OBAA (2.5-7 mg/kg i.v.)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

428.65

Formula

C28H44O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)/C=C/C(C1=CC=C(CCCCCCCCCCCCCCCCCC)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (58.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3329 mL 11.6645 mL 23.3291 mL
5 mM 0.4666 mL 2.3329 mL 4.6658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3329 mL 11.6645 mL 23.3291 mL 58.3226 mL
5 mM 0.4666 mL 2.3329 mL 4.6658 mL 11.6645 mL
10 mM 0.2333 mL 1.1665 mL 2.3329 mL 5.8323 mL
15 mM 0.1555 mL 0.7776 mL 1.5553 mL 3.8882 mL
20 mM 0.1166 mL 0.5832 mL 1.1665 mL 2.9161 mL
25 mM 0.0933 mL 0.4666 mL 0.9332 mL 2.3329 mL
30 mM 0.0778 mL 0.3888 mL 0.7776 mL 1.9441 mL
40 mM 0.0583 mL 0.2916 mL 0.5832 mL 1.4581 mL
50 mM 0.0467 mL 0.2333 mL 0.4666 mL 1.1665 mL
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OBAA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OBAA134531-42-3PhospholipaseApoptosisphospholipase-A2 PLA2Ca2+bronchospasmolysisInhibitorinhibitorinhibit

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