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LDN-0044878

LDN-0044878 is a PAK3 inhibitor. LDN-0044878 inhibits the proliferation or induces the death of p53-deficient cells. LDN-0044878 exhibits moderate trypanocidal activity against Trypanosoma brucei, but does not directly inhibit the core target Rhodesain. LDN-0044878 can be used in studies related to cervical adenocarcinoma and Trypanosoma brucei infection.

For research use only. We do not sell to patients.

CAS No.: 296246-47-4
Formula: C₂₈H₂₂N₂OS
Molecular Weight:434.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LDN-0044878 Chemical Structure

CAS No.: 296246-47-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PAK3

All PAK Isoforms :

All Parasite Isoforms :

In Vitro

LDN-0044878 (75-150 h) reduces the viability of HeLa cells, with EC₅₀ values of 10.7 μM (75 h), 15.5 μM (100 h) and 11.1 μM (150 h)^[1].
LDN-0044878 (Compound 19) exhibits moderate trypanocidal activity, with an IC₅₀ of 14.75 against T. brucei^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 296246-47-4
Molecular Weight 434.56
Formula C₂₈H₂₂N₂OS
SMILES

N1=C(NC(C2=CC=C(SC=3C=CC=CC3)C=C2)=C1C=4C=CC=CC4)C=5C=CC(OC)=CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Amy Baldwin, et al. Compositions and method for inhibiting tumor growth. WO2010141738A2.

[2]. Jefferson T, et al. Screening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal Activity. Chem Biol Drug Des. 2016;87(1):154-158. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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LDN-0044878

All PAK Isoforms

All Parasite Isoforms