Antitrypanosomal agent 26
Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC50 value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis.
For research use only. We do not sell to patients.
- CAS No.: 2601665-22-7
- Formula: C39H49BrNO3P
- Molecular Weight:690.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | EC50 |
2.35 μM
Compound: 18
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Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 31702921] |
Chemical Information
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CAS No. 2601665-22-7
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Molecular Weight 690.69
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Formula C39H49BrNO3P
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SMILES
O=C(OCCCCCCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=NC=CC=C3)C4=CC=C(O)C=C4C.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitrypanosomal agent 26 Related Classifications
HY-176253 Related Classifications
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