2. Anti-infection
  3. Parasite
  4. PEX5-PEX14 PPI-IN-4

PEX5-PEX14 PPI-IN-4 is a potent PEX14-PEX5 PPI inhibitor, with EC50 values of 7.78 μM, 27.5 μM and 9.31 μM against the protein-protein interactions of TbPEX14-PEX5, TcPEX14-PEX5 and HsPEX14-PEX5, respectively. PEX5-PEX14 PPI-IN-4 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. PEX5-PEX14 PPI-IN-4 shows cytotoxic activity against mammalian cells. PEX5-PEX14 PPI-IN-4 can be used in the research of human African trypanosomiasis and Chagas disease.

For research use only. We do not sell to patients.

PEX5-PEX14 PPI-IN-4

PEX5-PEX14 PPI-IN-4 Chemical Structure

CAS No. : 1884470-47-6

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PEX5-PEX14 PPI-IN-4 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

PEX5-PEX14 PPI-IN-4 is a potent PEX14-PEX5 PPI inhibitor, with EC50 values of 7.78 μM, 27.5 μM and 9.31 μM against the protein-protein interactions of TbPEX14-PEX5, TcPEX14-PEX5 and HsPEX14-PEX5, respectively. PEX5-PEX14 PPI-IN-4 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. PEX5-PEX14 PPI-IN-4 shows cytotoxic activity against mammalian cells. PEX5-PEX14 PPI-IN-4 can be used in the research of human African trypanosomiasis and Chagas disease[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 EC50
6.5 μM
Compound: 61
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 66 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 66 hrs by resazurin dye based fluorescence assay
[PMID: 31860309]
In Vitro

PEX5-PEX14 PPI-IN-4 (Compound 61) inhibits T. brucei growth with an EC50 of 0.503 μM and HepG2 cell growth with an EC50 of 6.50 μM, yielding a selectivity index of 12.9[1].
PEX5-PEX14 PPI-IN-4 inhibits T. b. rhodesiense, T. cruzi, and L6 cell growth with IC50 values of 0.029 μM, 2.20 μM, and 1.82 μM, respectively, and has a selectivity index of <1 relative to T. cruzi[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PEX5-PEX14 PPI-IN-4 Related Antibodies
Molecular Weight

591.74

Formula

C36H41N5O3
CAS No.
SMILES

O=C(C1=NN(CCNC(C)(CO)C)C2=C1CN(CC2)CC3=CC=C(C4=C3C=CC=C4)OC)NCC5=CC=CC6=C5C=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PEX5-PEX14 PPI-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEX5-PEX14 PPI-IN-41884470-47-6ParasiteTbPEX14Trypanosoma brucei rhodesienseTrypanosoma bruceiPEX14-PEX5 protein-protein interactionsL6 cellHepG2 cellhuman african trypanosomiasischagas diseaseHomo sapiensTrypanosoma cruziInhibitorinhibitorinhibit

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