1884470-47-6
Chemical Structure
PEX5-PEX14 PPI-IN-4
- CAS No.: 1884470-47-6
- Formula:C36H41N5O3
- Molecular Weight:591.74
InChIKey: MZJWSMMILGDGIP-UHFFFAOYSA-N
SMILES: O=C(C1=NN(CCNC(C)(CO)C)C2=C1CN(CC2)CC3=CC=C(C4=C3C=CC=C4)OC)NCC5=CC=CC6=C5C=CC=C6
Biological Activity: PEX5-PEX14 PPI-IN-4 is a potent PEX14-PEX5 PPI inhibitor, with EC50 values of 7.78 μM, 27.5 μM and 9.31 μM against the protein-protein interactions of TbPEX14-PEX5, TcPEX14-PEX5 and HsPEX14-PEX5, respectively. PEX5-PEX14 PPI-IN-4 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. PEX5-PEX14 PPI-IN-4 shows cytotoxic activity against mammalian cells. PEX5-PEX14 PPI-IN-4 can be used in the research of human African trypanosomiasis and Chagas disease[1].
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PEX5-PEX14 PPI-IN-4 | PEX5-PEX14 PPI-IN-4 is a potent PEX14-PEX5 PPI inhibitor, with EC50 values of 7.78 μM, 27.5 μM and 9.31 μM against the protein-protein interactions of TbPEX14-PEX5, TcPEX14-PEX5 and HsPEX14-PEX5, respectively. PEX5-PEX14 PPI-IN-4 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. PEX5-PEX14 PPI-IN-4 shows cytotoxic activity against mammalian cells. PEX5-PEX14 PPI-IN-4 can be used in the research of human African trypanosomiasis and Chagas disease. | |||||||||||||||||||||
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Keywords
