Antitrypanosomal agent 7
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA.
For research use only. We do not sell to patients.
- CAS No.: 2492436-38-9
- Formula: C23H31Cl2N5O2
- Molecular Weight:480.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
IC50: 0.71 μM (T. brucei)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L6 | IC50 |
>250 μM
Compound: 18c
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Cytotoxicity against rat L6 cells incubated for 6 days by resazurin dye based assay
Cytotoxicity against rat L6 cells incubated for 6 days by resazurin dye based assay
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[PMID: 32927230] |
Chemical Information
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CAS No. 2492436-38-9
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Molecular Weight 480.43
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Formula C23H31Cl2N5O2
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SMILES
COC1=CC(C2=NC3=CC(C4=NCCN4)=CC=C3N2)=CC=C1OCCN(CC)CC.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitrypanosomal agent 7 Related Classifications
HY-147550 Related Classifications
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