2492436-38-9
Chemical Structure
Antitrypanosomal agent 7
- CAS No.: 2492436-38-9
- Formula:C23H31Cl2N5O2
- Molecular Weight:480.43
IUPAC Name: 2-(4-(5-(4,5-dihydro-1H-imidazol-2-yl)-1H-benzo[d]imidazol-2-yl)-2-methoxyphenoxy)-N,N-diethylethan-1-amine dihydrochloride
InChIKey: BLRAXFLBYZMCNC-UHFFFAOYSA-N
SMILES: COC1=CC(C2=NC3=CC(C4=NCCN4)=CC=C3N2)=CC=C1OCCN(CC)CC.[H]Cl.[H]Cl
Biological Activity: Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1].
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Antitrypanosomal agent 7 | Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA. | |||||||||||||||||||||
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Keywords
