2. Anti-infection
  3. Parasite
  4. PDEB1-IN-1

PDEB1-IN-1 (Compound 12b) is the derivative of Cilomilast (HY-10790), and serves as an inhibitor for TryPanosoma Brucei PDEB1 (TbrPDEB1) with an IC50 of 0.95 μM. PDEB1-IN-1 inhibits the proliferation of T. Brucei with an EC50 of 26 μM.

For research use only. We do not sell to patients.

PDEB1-IN-1

PDEB1-IN-1 Chemical Structure

CAS No. : 1622300-88-2

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PDEB1-IN-1 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

PDEB1-IN-1 (Compound 12b) is the derivative of Cilomilast (HY-10790), and serves as an inhibitor for TryPanosoma Brucei PDEB1 (TbrPDEB1) with an IC50 of 0.95 μM. PDEB1-IN-1 inhibits the proliferation of T. Brucei with an EC50 of 26 μM[1].

Cellular Effect
Cell Line Type Value Description References
Sf21 IC50
0.038 μM
Compound: 12b, NEU-730
Inhibition of human PDE4B expressed in Sf21 cells using cAMP substrate by scintillation proximity assay
Inhibition of human PDE4B expressed in Sf21 cells using cAMP substrate by scintillation proximity assay
[PMID: 25127163]
Molecular Weight

423.50

Formula

C25H29NO5
CAS No.
SMILES

N#C[C@]1(C2=CC(OCCCCOC3=CC=CC=C3)=C(C=C2)OC)CC[C@@H](CC1)C(O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PDEB1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDEB1-IN-11622300-88-2Parasitesleep diseaseT. bruceiInhibitorinhibitorinhibit

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