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Cat. No.: HY-119938

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Tuberculosis inhibitor 1

Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC₅₀ of 5 nM.

For research use only. We do not sell to patients.

CAS No.: 2230810-28-1
Formula: C₃₄H₃₇N₅O₃
Molecular Weight:563.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Tuberculosis inhibitor 1 Chemical Structure

CAS No.: 2230810-28-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC₅₀ of 5 nM^[1].

IC₅₀ & Target

EC50: 5 nM (Trypanosoma brucei)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	CC₅₀	>25000 nM Compound: 34, Epimeric mixture	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by celltiter glo assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by celltiter glo assay	[PMID: 30482621]
HUVEC	CC₅₀	18666 nM Compound: 34, Epimeric mixture	Cytotoxicity against HUVEC Cytotoxicity against HUVEC	[PMID: 30482621]

In Vitro

Tuberculosis inhibitor 1 is selective over other parasites, such as Trypanosoma cruzi and Plasmodium falciparum (T. cruzi EC₅₀ 8120 nM, P. falciparum EC₅₀ 3624 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2230810-28-1
Molecular Weight 563.69
Formula C₃₄H₃₇N₅O₃
SMILES

O=C(CC1=C(C)NC2=C1C=C(OC)C=C2)N(CCN(CC3CCOC3)C4)C4C5=NC=C(N5)C6=CC(C=CC=C7)=C7C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ferrigno F, et al. Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitorsof Trypanosoma brucei growth in vitro. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3689-3692. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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