Clathrin

Clathrin is the cytoplasma-located, cage-like vesicle proteins for membrane transport. Clathrin is the molecular scaffold of classical endocytosis for extracellular substances uptake, and the intracellular transport carrier across different membrane structures such as transport from the Golgi apparatus to the endoplasmic reticulum. Clathrin dysfunction could lead to neurodegenerative diseases, muscle diseases, or cancer^[1].

References:

[1]. Kirchhausen T, et al., Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol. 2014 May 1;6(5):a016725. [Content Brief]

Clathrin Related Products (5):

By Effects:	Inhibitors (4) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-131683

ES9-17	Inhibitor	99.68%
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings.

HY-186018

Pitstop 2d	Inhibitor
Pitstop 2d is a Clathrin inhibitor with an IC₅₀ of <2 μM. Pitstop 2d binds to Clathrin N-terminal β-propeller domain, inhibits Clathrin function and dynamics and impairs VSV entry. Pitstop 2d inhibits Clathrin-mediated Endocytosis. Pitstop 2d does not inhibit clathrin-independent Endocytosis.

HY-186017

Pitstop 2c	Inhibitor	98.54%
Pitstop 2c is a Clathrin inhibitor with an IC₅₀ of <2 μM. Pitstop 2c binds to Clathrin N-terminal β-propeller domain, inhibits Clathrin function and dynamics and impairs VSV entry. Pitstop 2c inhibits Clathrin-mediated Endocytosis. Pitstop 2d does not inhibit clathrin-independent Endocytosis.

HY-181933

Clathrin-IN-5	Inhibitor
Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC₅₀ of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC₅₀ of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC₅₀ of 29.7 μM.

HY-125188

NEU-4438	Activator
NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model.

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