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  3. Pitstop 2

Pitstop 2 

Cat. No.: HY-115604 Purity: 99.54%
Handling Instructions

Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research.

For research use only. We do not sell to patients.

Pitstop 2 Chemical Structure

Pitstop 2 Chemical Structure

CAS No. : 1419320-73-2

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Based on 1 publication(s) in Google Scholar

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Description

Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research[1][2].

In Vitro

Pitstop 2 (20-40 μM; 30 min) inhibits the endocytosis of transferrin in J774A.1 macrophages and does not compromise cell viability[1].
Pitstop 2 (20-40 μM; 30 min) does not affect the internalization of cholera toxin B in J774A.1 macrophages[1].
Pitstop 2 (0.001-100 μM; 6 h) inhibits the mitotic spindle and impairs mitotic progression in HeLa cells[2].
Pitstop 2 (1-30 μM; 24 h) induces apoptosis and inhibits cell growth in dividing cancer cells[2].
Pitstop 2 (1-30 μM; 48 h) does not affect the growth and viability of non-tumourigenic NIH3T3 fibroblasts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: HeLa cells
Concentration: 1, 3, 10, 30 μM
Incubation Time: 24 hours
Result: Reduced the total number of viable HeLa cells markedly in a dose-dependent manner.
Molecular Weight

473.36

Formula

C₂₀H₁₃BrN₂O₃S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (132.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1126 mL 10.5628 mL 21.1256 mL
5 mM 0.4225 mL 2.1126 mL 4.2251 mL
10 mM 0.2113 mL 1.0563 mL 2.1126 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Pitstop 2
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HY-115604
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