1. Apoptosis
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  3. Pitstop 2

Pitstop 2 

Cat. No.: HY-115604
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Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research.

For research use only. We do not sell to patients.

Pitstop 2 Chemical Structure

Pitstop 2 Chemical Structure

CAS No. : 1419320-73-2

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Description

Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research[1][2].

In Vitro

Pitstop 2 (20-40 μM; 30 min) inhibits the endocytosis of transferrin in J774A.1 macrophages and does not compromise cell viability[1].
Pitstop 2 (20-40 μM; 30 min) does not affect the internalization of cholera toxin B in J774A.1 macrophages[1].
Pitstop 2 (0.001-100 μM; 6 h) inhibits the mitotic spindle and impairs mitotic progression in HeLa cells[2].
Pitstop 2 (1-30 μM; 24 h) induces apoptosis and inhibits cell growth in dividing cancer cells[2].
Pitstop 2 (1-30 μM; 48 h) does not affect the growth and viability of non-tumourigenic NIH3T3 fibroblasts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: HeLa cells
Concentration: 1, 3, 10, 30 μM
Incubation Time: 24 hours
Result: Reduced the total number of viable HeLa cells markedly in a dose-dependent manner.
Molecular Weight

473.36

Formula

C₂₀H₁₃BrN₂O₃S₂

CAS No.

1419320-73-2

SMILES

O=S(C1=C2C=CC=CC2=CC=C1)(NC(S/C3=C\C4=CC=C(Br)C=C4)=NC3=O)=O.[(Z)]

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Pitstop 2Pitstop2Pitstop-2Apoptosisclathrinclathrin-mediatedendocytosisCMEcancerInhibitorinhibitorinhibit

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