1419320-73-2
1419320-73-2
Chemical Structure
Pitstop 2
- CAS No.: 1419320-73-2
- Formula:C20H13BrN2O3S2
- Molecular Weight:473.36
IUPAC Name: (Z)-N-(5-(4-bromobenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)naphthalene-1-sulfonamide
InChIKey: CGDLWHGPJPVPDU-ATVHPVEESA-N
SMILES: O=S(C1=C2C=CC=CC2=CC=C1)(NC(S/C3=C\C4=CC=C(Br)C=C4)=NC3=O)=O
Biological Activity: Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research[1][2].
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Pitstop 2 | 98.42% | Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research. | ||||||||||||||||||||
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Pitstop 2 (Standard) | ≥98% | Pitstop 2 (Standard) is the analytical standard of Pitstop 2 (HY-115604). This product is intended for research and analytical applications. Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research. | ||||||||||||||||||||
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References
- [1]. Kumar GA, et, al. Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis. Sci Rep. 2019 Sep 2; 9(1): 12636. [Content Brief]
- [2]. Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4. [Content Brief]
