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Referencia número: HY-P4092

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HN-1

HN-1 is a tumor-specific internalizing peptide. HN-1 internalizes through receptor-mediated, energy-dependent, Clathrin-mediated endocytosis. HN-1 preferentially binds to invasive head and neck squamous cell carcinoma and is selectively internalized. HN-1 enhances the transfer of liposome-DNA complexes to head and neck squamous cell carcinoma. HN-1 can be used for research on head and neck squamous cell carcinoma.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 386223-83-2
Fòrmula: C₅₇H₉₆N₁₈O₁₈
Peso molecular:1321.48

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

HN-1 Chemical Structure

No. CAS: 386223-83-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

In Vitro

HN-1 is internalized by attached HNSCC cell lines such as MDA177Tu, UMSCC1, SCC-25, CAL-27, and FaDu, but not by suspended HNSCC cells or normal HOK16B/NOE/NHDF cells, via energy-dependent clathrin-mediated endocytosis and endosomal localization^[2].
HN-1 (>500 μM) blocks FITC-labeled HN-1 internal fluorescence in HNSCC cells, supporting specific HN-1-mediated uptake rather than free-dye labeling^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Cy5-labeled HN-1-PKCε is taken up by HNSCC xenograft tumors and reduces overall HNSCC tumor growth in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 386223-83-2
Peso molecular 1321.48
Fòrmula C₅₇H₉₆N₁₈O₁₈
Sequence

Thr-Ser-Pro-Leu-Asn-Ile-His-Asn-Gly-Gln-Lys-Leu
Sequence Shortening

TSPLNIHNGQKL
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Hong FD, et al. Isolation of a peptide for targeted drug delivery into human head and neck solid tumors. Cancer Res. 2000 Dec 1;60(23):6551-6. PMID: 11118031. [Content Brief]

[2]. Hong FU, et al. Tumor specifically internalizing peptide 'HN-1': Targeting the putative receptor retinoblastoma-regulated discoidin domain receptor 1 involved in metastasis. World journal of clinical oncology. 2022 May 24;13(5):323-338.

[3]. Wright CL, et al. Advancing theranostics with tumor-targeting peptides for precision otolaryngology. World journal of otorhinolaryngology - head and neck surgery. 2016 Jun;2(2):98-108.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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