339025-18-2
Chemical Structure
Clathrin-IN-5
- CAS No.: 339025-18-2
- Formula:C16H10ClNO3
- Molecular Weight:299.71
InChIKey: XCMJGNUGOYSYEP-UHFFFAOYSA-N
SMILES: OC1=CC(NC(C(C2=C3C=CC=C2)=O)=C(Cl)C3=O)=CC=C1
Biological Activity: Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC50 of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC50 of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC50 of 29.7 μM[1].
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Clathrin-IN-5 | Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC50 of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC50 of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC50 of 29.7 μM. | |||||||||||||||||||||
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Keywords
