Clathrin-IN-5
Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC50 of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC50 of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC50 of 29.7 μM.
For research use only. We do not sell to patients.
- CAS No.: 339025-18-2
- Formula: C16H10ClNO3
- Molecular Weight:299.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Dynamin I 29.7 μM (IC50) |
Clathrin-IN-5 potently inhibits the Clathrin N-terminal domain-amphiphysin protein-protein interaction with an IC50 of 2.77 ± 0.9 μM in an ELISA-based binding assay[1].
Clathrin-IN-5 inhibits clathrin-mediated endocytosis in U2OS osteosarcoma cells with an IC50 of 4.6 ± 0.5 μM[1].
Clathrin-IN-5 inhibits full-length human dynamin I GTPase activity with an IC50 of 29.7 ± 3.3 μM in an in vitro colorimetric assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 339025-18-2
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Molecular Weight 299.71
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Formula C16H10ClNO3
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SMILES
OC1=CC(NC(C(C2=C3C=CC=C2)=O)=C(Cl)C3=O)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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