Clathrin-IN-5 

Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC₅₀ of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC₅₀ of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC₅₀ of 29.7 μM^[1].

Clathrin-IN-5 potently inhibits the Clathrin N-terminal domain-amphiphysin protein-protein interaction with an IC₅₀ of 2.77 ± 0.9 μM in an ELISA-based binding assay^[1].
Clathrin-IN-5 inhibits clathrin-mediated endocytosis in U2OS osteosarcoma cells with an IC₅₀ of 4.6 ± 0.5 μM^[1].
Clathrin-IN-5 inhibits full-length human dynamin I GTPase activity with an IC₅₀ of 29.7 ± 3.3 μM in an in vitro colorimetric assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

299.71

C₁₆H₁₀ClNO₃

339025-18-2

OC1=CC(NC(C(C2=C3C=CC=C2)=O)=C(Cl)C3=O)=CC=C1

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• [1]. O'Brien NS, et al. DFT guided design of novel quinone bioisosteres as inhibitors of the clathrin N-terminal domain-amphiphysin protein-protein interaction. Dihydroquinazolin-4(1H)-ones and quinazolin-3(4H)-ones. Eur J Med Chem. Published online March 2, 2026.  [Content Brief]