2. Cytoskeleton
  3. Clathrin
  4. Pitstop 2c

Pitstop 2c is a Clathrin inhibitor with an IC50 of <2 μM. Pitstop 2c binds to Clathrin N-terminal β-propeller domain, inhibits Clathrin function and dynamics and impairs VSV entry. Pitstop 2c inhibits Clathrin-mediated Endocytosis. Pitstop 2d does not inhibit clathrin-independent Endocytosis.

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Pitstop 2c

Pitstop 2c Chemical Structure

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Pitstop 2c Related Antibodies

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Description

Pitstop 2c is a Clathrin inhibitor with an IC50 of <2 μM. Pitstop 2c binds to Clathrin N-terminal β-propeller domain, inhibits Clathrin function and dynamics and impairs VSV entry. Pitstop 2c inhibits Clathrin-mediated Endocytosis. Pitstop 2d does not inhibit clathrin-independent Endocytosis[1].

IC50 & Target

IC50: <2 μM (Clathrin TD)[1]
Molecular Weight

486.56

Formula

C26H18N2O4S2
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(C1=C2C=CC=CC2=CC=C1)(NC(S/C3=C\C4=C(C=CC=C4)OC5=CC=CC=C5)=NC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
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Pitstop 2c Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pitstop 2cClathrinInhibitorinhibitorinhibit

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