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Results for "

Tyrphostin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Apoptosis (6) Autophagy (1) Bcr-Abl (3) c-Kit (3) c-Met/HGFR (1) Casein Kinase (1) CDK (1) Dynamin (1) EGFR (29) Endogenous Metabolite (1) Environmental Pollutants (1) ERK (2) FLT3 (2) GPR35 (2) HCV (3) HIV Integrase (1) IGF-1R (3) Influenza Virus (5) Insulin Receptor (4) Interleukin Related (2) JAK (3) Mitosis (2) PDGFR (7) Phosphatase (1) Ras (1) Reference Standards (12) Reverse Transcriptase (1) Ser/Thr Protease (1) STAT (5) Topoisomerase (1) Trk Receptor (1) Tyrosinase (3) VEGFR (4)
By Research Areas:	Cancer (42) Cardiovascular Disease (7) Endocrinology (4) Infection (6) Inflammation/Immunology (14) Metabolic Disease (7) Neurological Disease (1)

By Targets:

Adrenergic Receptor (1)

Apoptosis (6)

Autophagy (1)

Bcr-Abl (3)

c-Kit (3)

c-Met/HGFR (1)

Casein Kinase (1)

CDK (1)

Dynamin (1)

EGFR (29)

Endogenous Metabolite (1)

Environmental Pollutants (1)

ERK (2)

FLT3 (2)

GPR35 (2)

HCV (3)

HIV Integrase (1)

IGF-1R (3)

Influenza Virus (5)

Insulin Receptor (4)

Interleukin Related (2)

JAK (3)

Mitosis (2)

PDGFR (7)

Phosphatase (1)

Ras (1)

Reference Standards (12)

Reverse Transcriptase (1)

Ser/Thr Protease (1)

STAT (5)

Topoisomerase (1)

Trk Receptor (1)

Tyrosinase (3)

VEGFR (4)

By Research Areas:

Cancer (42)

Cardiovascular Disease (7)

Endocrinology (4)

Infection (6)

Inflammation/Immunology (14)

Metabolic Disease (7)

Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12000

AG490 Maximum Cited Publications 165 Publications Verification Tyrphostin AG490; Tyrphostin B42	EGFR STAT JAK Autophagy	Cancer
AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

HY-13524

AG-1478 45+ Cited Publications Tyrphostin AG-1478; NSC 693255	EGFR HCV Influenza Virus	Infection Cardiovascular Disease Metabolic Disease Cancer
AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC₅₀ of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

HY-10253

AG1024 5+ Cited Publications Tyrphostin AG 1024	IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC₅₀ of 7 μM. AG1024 inhibits phosphorylation of IR (IC₅₀=57 μM). AG1024 induces apoptosis and has anti-cancer activity .

HY-15644

Tyrphostin 23 5+ Cited Publications Tyrphostin A23; RG-50810; AG 18	EGFR	Cancer
Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC₅₀ and K_iof 35 and 11 μM, respectively.

HY-15511

Tyrphostin A9 5+ Cited Publications Tyrphostin 9; Malonoben	Environmental Pollutants VEGFR PDGFR Influenza Virus	Infection Cancer
Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.

HY-13894

Tyrphostin AG1296 3 Publications Verification AG1296	PDGFR c-Kit FLT3 Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC₅₀ of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC₅₀ in the micromolar range .

HY-108330

AG126 3 Publications Verification Tyrphostin AG126	ERK Mitosis	Inflammation/Immunology
AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research .

HY-100037

NT157 2 Publications Verification Tyrphostin NT157	Insulin Receptor STAT	Endocrinology Cancer
NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway .

HY-19326

SU1498 5+ Cited Publications AG 1498; Tyrphostin SU 1498	VEGFR	Inflammation/Immunology Cancer
SU1498 (AG 1498) is a selective inhibitor of the VEGFR2; inhibits Flk-1 with an IC₅₀ of value of 700 nM .

HY-20878

Tyrphostin AG 879 3 Publications Verification AG 879	Trk Receptor EGFR Apoptosis	Cancer
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC₅₀ of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC₅₀ of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity .

HY-15336

AG 555 Tyrphostin AG 555	EGFR Reverse Transcriptase	Cancer
AG 555 (Tyrphostin AG 555), a potent antiretroviral agent, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation .

HY-101042

AG-494 Tyrphostin AG 494	EGFR CDK	Cancer
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC₅₀=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC₅₀s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis .

HY-123572

Bis-T-23 AG1717	Dynamin HIV Integrase	Infection Metabolic Disease Inflammation/Immunology
Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD) .

HY-101960A

Tyrphostin A51 AG-183	EGFR	Cancer
Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

HY-101961

Tyrphostin AG 1288 AG 1288	c-Kit	Inflammation/Immunology
Tyrphostin AG 1288 is a potent Tyrosine Kinase inhibitor. Tyrphostin AG 1288 inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro .

HY-101007A

*(+)-Tyrphostin* B44** Tyrphostin AG 835; Tyrphostin B 50	EGFR	Cancer
(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities .

HY-100499

Tyrphostin AG 528 1 Publications Verification Tyrphostin B66; AG 528	EGFR	Cancer
Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC₅₀s of 4.9 and 2.1 μM, respectively. Tyrphostin AG 528 (Tyrphostin B66) is a protein tyrosine kinase inhibitor, with IC₅₀s of 4.9 μM for epidermal growth factor receptors (EGFR) and 2.1 μM for ErbB2 . Tyrphostin AG 528 is also an anticancer agent .

HY-100962

(E)-AG 99 1 Publications Verification (E)-Tyrphostin 46; (E)-Tyrphostin AG 99	EGFR	Cancer
(E)-AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor .

HY-16668

Tyrphostin A1 1 Publications Verification Tyrphostin 1; AG9	Interleukin Related	Inflammation/Immunology
Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.

HY-112474

Tyrphostin AG 112	EGFR	Cancer
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor .

HY-118532

Tyrphostin AG30 1 Publications Verification AG30	EGFR	Cancer
Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts .

HY-119757

Tyrphostin AG1433 SU1433; AG1433	PDGFR VEGFR	Cancer
Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC₅₀s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation .

HY-135680

*I-OMe-Tyrphostin* AG 538** 1 Publications Verification I-OMe-AG 538	IGF-1R	Metabolic Disease Cancer
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC₅₀?of 1 μM .

HY-117718

AG957 Tyrphostin AG957; NSC 654705	Bcr-Abl	Cancer
AG957 (Tyrphostin AG957;NSC 654705) is a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity . AG957 is a bcr/abl kinase inhibitor with an IC₅₀ of 2.9 μM for p210 ^bcr/abl autokinase activity .

HY-101429

RG13022 1 Publications Verification Tyrphostin RG13022	EGFR	Cancer
RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor with an IC₅₀ of 4 μM.

HY-101426

RG14620 1 Publications Verification Tyrphostin RG14620	EGFR	Cancer
RG14620 is an EGFR inhibitor with an IC₅₀ of 3 μM.

HY-15844

AG-825 1 Publications Verification Tyrphostin AG-825	EGFR Apoptosis Adrenergic Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
AG-825 is a selective, ATP-competitive, tyrosine phosphorylation ErbB2 inhibitor with an IC₅₀ of 0.35 μM. AG825 significantly accelerates Apoptosis of human neutrophils. AG-825 increases β1AR density. AAG-825 has anticancer and anti-inflammatory activities. AAG-825 can be used in cardiovascular disease research .

HY-118143

AG-1801	Endogenous Metabolite	Others
AG-1801, a nitrobenzopyridine derivative, is a tyrosine phosphorylation inhibitor. AG-1801 can induce the disintegration of the microtubule network in living cells, and does not inhibit microtubule polymerization in vitro. AG-1801 can be used for the study of microtubule-related signaling pathways .

HY-101958

Tyrphostin 25 AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875	EGFR GPR35	Inflammation/Immunology Cancer
Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC₅₀ value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC₅₀ of 5.3 µM .

HY-13894R

Tyrphostin AG1296 (Standard) AG1296 (Standard)	PDGFR c-Kit FLT3 Apoptosis Reference Standards	Cardiovascular Disease Inflammation/Immunology Cancer
Tyrphostin AG1296 (Standard) is the analytical standard of Tyrphostin AG1296. This product is intended for research and analytical applications. Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .

HY-13524A

AG-1478 hydrochloride Tyrphostin AG-1478 hydrochloride; NSC 693255 hydrochloride	EGFR HCV Influenza Virus	Infection Cardiovascular Disease Metabolic Disease Cancer
AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC₅₀ of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV) .

HY-101041

(E)-AG 556 (E)-Tyrphostin AG 556	EGFR	Inflammation/Immunology
(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production .

HY-15511R

Tyrphostin A9 (Standard) Tyrphostin 9 (Standard); Malonoben (Standard)	VEGFR Influenza Virus PDGFR Reference Standards	Infection Cancer
Tyrphostin A9 (Standard) is the analytical standard of Tyrphostin A9. This product is intended for research and analytical applications. Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.

HY-W174279

Tyrphostin 8	EGFR Ras Phosphatase	Metabolic Disease
Tyrphostin 8 is a tyrosine kinase, with an IC₅₀ of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC₅₀=21 μM) .

HY-101960

*(Z)-Tyrphostin* A51** (Z)-AG-183	EGFR	Others
(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

HY-107459

(E/Z)-AG490 1 Publications Verification (E/Z)-Tyrphostin AG490; (E/Z)-Tyrphostin B42	EGFR STAT JAK	Cancer
(E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

HY-118964

Tyrphostin AG 568	Bcr-Abl	Others
Tyrphostin AG 568 is a tyrphostin tyrosine kinase inhibitor that induces erythroid differentiation. Tyrphostin AG 568 can be utilized in research related to autologous bone marrow transplantation .

HY-100962A

AG 99 Tyrphostin 46; Tyrphostin AG 99	Tyrosinase	Cancer
AG 99 (Tyrphostin 46), a tyrphostin derivative, is a tyrosine kinase inhibitor that increases sister chromatid exchange frequency in transformed CHO-K1 and primary CHE cells. AG 99 is promising for research of proliferative diseases .

HY-116111

AG 370	PDGFR	Cardiovascular Disease
AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC₅₀ of 20 μM). AG 370 displays weak inhibition of the EGF receptor .

HY-101959A

Tyrphostin 47	Ser/Thr Protease	Cancer
Tyrphostin 47 is a nonspecific inhibitor of WNK1. Tyrphostin 47 is a protein tyrosine kinase inhibitor. Tyrphostin 47 inhibits smooth-muscle cell proliferation

HY-15644R

Tyrphostin 23 (Standard) Tyrphostin A23 (Standard); RG-50810 (Standard); AG 18 (Standard)	EGFR Reference Standards	Cancer
Tyrphostin 23 (Standard) is the analytical standard of Tyrphostin 23. This product is intended for research and analytical applications. Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.

HY-101958R

Tyrphostin 25 (Standard) AG82 (Standard); Tyrphostin A 25 (Standard); Tyrphostin AG 82 (Standard); RG-50875 (Standard)	Reference Standards EGFR GPR35	Inflammation/Immunology Cancer
Tyrphostin 25 (Standard) (AG82 (Standard)) is the analytical standard of Tyrphostin 25 (HY-101958). This product is intended for research and analytical applications. Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC₅₀ value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC₅₀ of 5.3 µM .

HY-169755

Tyrphostin 63	EGFR	Cancer
Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor with IC₅₀ and K_i values are 375 and 123 μM, respectively .

HY-120036

Tyrphostin AG1112	Casein Kinase Tyrosinase	Cancer
Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210 ^bcr-abl tyrosine kinase, with IC₅₀ values of 2, 15, 20 μM in p210 ^bcr-abl, EGFR and PDGFR cells, respectively .

HY-119757A

Tyrphostin AG1433 hydrochloride SU1433 hydrochloride; AG1433 hydrochloride	PDGFR	Inflammation/Immunology
Tyrphostin AG 1433 is a specific and potent inhibitor of PDGFR-β and of KDR/Flk-1. Tyrphostin AG 1433 acts as an angiogenesis inhibitor .

HY-101959

Tyrphostin AG213 AG213	EGFR Topoisomerase	Cancer
Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC₅₀=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC₅₀=2.4 μM) and topoisomerase II (IC₁₀₀=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells .

HY-125350

Entacapone acid Tyrphostin AG1290	c-Met/HGFR	Metabolic Disease
Entacapone acid (Tyrphostin AG1290) is a tyrosine kinase inhibitor. Entacapone acid reduces hepatic protein synthesis rate (HPS) in vivo .

HY-13524R

AG-1478 (Standard) Tyrphostin AG-1478 (Standard); NSC 693255 (Standard)	EGFR HCV Influenza Virus Reference Standards	Infection Cardiovascular Disease Metabolic Disease Cancer
AG-1478 (Standard) is the analytical standard of AG-1478. This product is intended for research and analytical applications. AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

HY-117718R

AG957 (Standard) Tyrphostin AG957 (Standard); NSC 654705 (Standard)	Bcr-Abl Reference Standards	Cancer
AG957 (Standard) is the analytical standard of AG957. This product is intended for research and analytical applications. AG957 (Tyrphostin AG957;NSC 654705) is a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity . AG957 is a bcr/abl kinase inhibitor with an IC50 of 2.9 μM for p210bcr/abl autokinase activity .

HY-108330R

AG126 (Standard) Tyrphostin AG126 (Standard)	ERK Mitosis Reference Standards	Inflammation/Immunology
AG126 (Standard) is the analytical standard of AG126. This product is intended for research and analytical applications. AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research .

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Tyrphostin

Inhibitors & Agonists