2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Tyrphostin AG-808

Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats.

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Tyrphostin AG-808

Tyrphostin AG-808 Chemical Structure

CAS No. : 160953-95-7

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Tyrphostin AG-808 Related Antibodies

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Description

Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
53.24 μM
Compound: AG808
Inhibition of PTK6 (unknown origin) expressed in HEK293 cells assessed as decrease in tyrosine phosphorylation by chemiluminescence assay
Inhibition of PTK6 (unknown origin) expressed in HEK293 cells assessed as decrease in tyrosine phosphorylation by chemiluminescence assay
[PMID: 25205190]
In Vivo

Tyrphostin AG-808 (local perivascular controlled-release; 21 days) fails to reduce neointimal formation in a rat carotid artery restenosis model and causes arterial media disruption in some animals[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

304.30

Formula

C18H12N2O3
CAS No.
SMILES

O=C(C1=CC(O)=C(C=C1)O)/C(C#N)=C/C2=CNC3=CC=CC=C23
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tyrphostin AG-808 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Tyrphostin AG-808160953-95-7Tyrphostin AG808Tyrphostin AG 808Tyrosinaseratsmedial disruptionrat carotid artery restenosis modelarterial media disruptionneointimal formationperivascular implantsprotein tyrosine kinase inhibitorInhibitorinhibitorinhibit

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