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Cat. No.: HY-182713

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Tyrphostin AG-808

Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats.

For research use only. We do not sell to patients.

CAS No.: 160953-95-7
Formula: C₁₈H₁₂N₂O₃
Molecular Weight:304.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tyrphostin AG-808 Chemical Structure

CAS No.: 160953-95-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	53.24 μM Compound: AG808	Inhibition of PTK6 (unknown origin) expressed in HEK293 cells assessed as decrease in tyrosine phosphorylation by chemiluminescence assay Inhibition of PTK6 (unknown origin) expressed in HEK293 cells assessed as decrease in tyrosine phosphorylation by chemiluminescence assay	[PMID: 25205190]

In Vivo

Tyrphostin AG-808 (local perivascular controlled-release; 21 days) fails to reduce neointimal formation in a rat carotid artery restenosis model and causes arterial media disruption in some animals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 160953-95-7
Molecular Weight 304.30
Formula C₁₈H₁₂N₂O₃
SMILES

O=C(C1=CC(O)=C(C=C1)O)/C(C#N)=C/C2=CNC3=CC=CC=C23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Golomb G, Fishbein I. Tyrphostins, inhibitors of protein tyrosine kinase, in restenosis. Advanced drug delivery reviews. 1997 Feb 15;24(1):53-62.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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