1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    Apoptosis
  2. EGFR
    Apoptosis
  3. AG-825

AG-825 (Synonyms: Tyrphostin AG-825)

Cat. No.: HY-15844
Handling Instructions

AG-825 (Tyrphostin AG-825) is a selective and ATP-competitive ErbB2 inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35 μM. AG-825 displays anti-cancer activity. AG825 significantly accelerates apoptosis of human neutrophils. AG-825 is a potential agent for overcoming Mn-induced neurotoxicity or AD development.

For research use only. We do not sell to patients.

AG-825 Chemical Structure

AG-825 Chemical Structure

CAS No. : 149092-50-2

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Description

AG-825 (Tyrphostin AG-825) is a selective and ATP-competitive ErbB2 inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35 μM. AG-825 displays anti-cancer activity[1][2][3]. AG825 significantly accelerates apoptosis of human neutrophils[4]. AG-825 is a potential agent for overcoming Mn-induced neurotoxicity or AD development[5].

IC50 & Target[2]

ErbB2

0.35 μM (IC50)

EGFR

19 μM (IC50)

Molecular Weight

397.47

Formula

C₁₉H₁₅N₃O₃S₂

CAS No.

149092-50-2

SMILES

O=C(N)/C(C#N)=C/C1=CC(OC)=C(O)C(CSC2=NC3=CC=CC=C3S2)=C1

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Keywords:

AG-825Tyrphostin AG-825AG825AG 825Tyrphostin AG825Tyrphostin AG 825EGFRApoptosisEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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AG-825
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HY-15844
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