1. Protein Tyrosine Kinase/RTK
  2. PDGFR
    VEGFR
  3. Tyrphostin AG1433

Tyrphostin AG1433 (Synonyms: SU1433; AG1433)

Cat. No.: HY-119757
Handling Instructions

Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation.

For research use only. We do not sell to patients.

Tyrphostin AG1433 Chemical Structure

Tyrphostin AG1433 Chemical Structure

CAS No. : 168835-90-3

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Description

Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation[1][2][3][4].

IC50 & Target[2]

Flk-1

9.3 μM (IC50)

PDGFRβ

5 μM (IC50)

In Vitro

Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity in glioblastoma cells[1].

Cell Viability Assay[1]

Cell Line: GB8B cells
Concentration: 0.1 μM, 1 μM, 5 μM, 10 μM, 20 μM, 30 μM, 50 μM, 60 μM, 100 μM
Incubation Time: 72 hours
Result: Induced significant cell death in GB8B cells in a concentration-dependent manner.
In Vivo

Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets[2].

Molecular Weight

266.29

Formula

C₁₆H₁₄N₂O₂

CAS No.

168835-90-3

SMILES

OC1=CC=C(C2=NC3=CC(C)=C(C)C=C3N=C2)C=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Tyrphostin AG1433SU1433 AG1433Tyrphostin AG 1433Tyrphostin AG-1433SU 1433SU-1433AG1433AG 1433AG-1433PDGFRVEGFRPlatelet-derived growth factor receptorVascular endothelial growth factor receptorPDGFRβVEGFR-2cytotoxicityATMangiogenesis,tyrosinekinasesInhibitorinhibitorinhibit

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Tyrphostin AG1433
Cat. No.:
HY-119757
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