1. Protein Tyrosine Kinase/RTK
  2. PDGFR
    VEGFR
  3. Tyrphostin AG1433

Tyrphostin AG1433 (Synonyms: SU1433; AG1433)

Cat. No.: HY-119757 Purity: 99.20%
Handling Instructions

Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation.

For research use only. We do not sell to patients.

Tyrphostin AG1433 Chemical Structure

Tyrphostin AG1433 Chemical Structure

CAS No. : 168835-90-3

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Description

Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation[1][2][3][4].

IC50 & Target[2]

Flk-1

9.3 μM (IC50)

PDGFRβ

5 μM (IC50)

In Vitro

Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity in glioblastoma cells[1].

Cell Viability Assay[1]

Cell Line: GB8B cells
Concentration: 0.1 μM, 1 μM, 5 μM, 10 μM, 20 μM, 30 μM, 50 μM, 60 μM, 100 μM
Incubation Time: 72 hours
Result: Induced significant cell death in GB8B cells in a concentration-dependent manner.
In Vivo

Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets[2].

Molecular Weight

266.29

Formula

C₁₆H₁₄N₂O₂

CAS No.

168835-90-3

SMILES

OC1=CC=C(C2=NC3=CC(C)=C(C)C=C3N=C2)C=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (234.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7553 mL 18.7765 mL 37.5530 mL
5 mM 0.7511 mL 3.7553 mL 7.5106 mL
10 mM 0.3755 mL 1.8777 mL 3.7553 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Tyrphostin AG1433SU1433 AG1433Tyrphostin AG 1433Tyrphostin AG-1433SU 1433SU-1433AG1433AG 1433AG-1433PDGFRVEGFRPlatelet-derived growth factor receptorVascular endothelial growth factor receptorPDGFRβVEGFR-2cytotoxicityATMangiogenesis,tyrosinekinasesInhibitorinhibitorinhibit

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Tyrphostin AG1433
Cat. No.:
HY-119757
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