168835-90-3
168835-90-3
Chemical Structure
Tyrphostin AG1433
Synonym(s): SU1433; AG1433
- CAS No.: 168835-90-3
- Formula:C16H14N2O2
- Molecular Weight:266.29
IUPAC Name: 4-(6,7-dimethylquinoxalin-2-yl)benzene-1,2-diol
InChIKey: SMKFYHOKXJUJOT-UHFFFAOYSA-N
SMILES: OC1=CC=C(C2=NC3=CC(C)=C(C)C=C3N=C2)C=C1O
Biological Activity: Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tyrphostin AG1433 | 99.08% | Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation. | ||||||||||||||||||||
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References
- [1]. Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33. [Content Brief]
- [2]. Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5. [Content Brief]
- [3]. Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62. [Content Brief]
- [4]. Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272(51):32521-7. [Content Brief]
Keywords
