1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

CU-CPT-9b (Synonyms: TLR8-specific antagonist 1)

Cat. No.: HY-112051 Purity: 99.05%
Handling Instructions

CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.

For research use only. We do not sell to patients.

CU-CPT-9b Chemical Structure

CU-CPT-9b Chemical Structure

CAS No. : 2165340-32-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.

IC50 & Target[1]

TLR8

0.7 nM (IC50)

In Vitro

CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT-9b with a Kd of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT-9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT-9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT-9b as compared to TLR8/CU-CPT8m[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7692 mL 18.8459 mL 37.6918 mL
5 mM 0.7538 mL 3.7692 mL 7.5384 mL
10 mM 0.3769 mL 1.8846 mL 3.7692 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

265.31

Formula

C₁₇H₁₅NO₂

CAS No.

2165340-32-7

SMILES

OC1=CC=C(C2=CC=NC3=CC(OC)=CC=C23)C=C1C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
CU-CPT-9b
Cat. No.:
HY-112051
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CU-CPT-9b

Cat. No.: HY-112051