1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. CU-CPT-9a

CU-CPT-9a 

Cat. No.: HY-112667 Purity: 98.62%
Handling Instructions

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.

For research use only. We do not sell to patients.

CU-CPT-9a Chemical Structure

CU-CPT-9a Chemical Structure

CAS No. : 2165340-32-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

    CU-CPT-9a purchased from MCE. Usage Cited in: Eur J Pharmacol. 2019 Mar 5;846:12-22.

    The effect of CU-CPT-9a on the protein levels of MyD88 and p38.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.

    IC50 & Target[1]

    TLR8

    0.5 nM (IC50)

    In Vitro

    CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases[1].

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 150 mg/mL (565.38 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.7692 mL 18.8459 mL 37.6918 mL
    5 mM 0.7538 mL 3.7692 mL 7.5384 mL
    10 mM 0.3769 mL 1.8846 mL 3.7692 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (9.42 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (9.42 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (9.42 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Molecular Weight

    265.31

    Formula

    C₁₇H₁₅NO₂

    CAS No.

    2165340-32-7

    SMILES

    OC1=C(C)C=C(C=C1)C2=CC=NC3=CC(OC)=CC=C32

    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    CU-CPT-9a
    Cat. No.:
    HY-112667
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    CU-CPT-9a

    Cat. No.: HY-112667