1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

CU-CPT-9a 

Cat. No.: HY-112667 Purity: 98.62%
Handling Instructions

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.

For research use only. We do not sell to patients.

CU-CPT-9a Chemical Structure

CU-CPT-9a Chemical Structure

CAS No. : 2162962-69-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.

IC50 & Target[1]

TLR8

0.5 nM (IC50)

In Vitro

CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases[1].

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (596.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9796 mL 19.8981 mL 39.7962 mL
5 mM 0.7959 mL 3.9796 mL 7.9592 mL
10 mM 0.3980 mL 1.9898 mL 3.9796 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.95 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.95 mM); Clear solution

References
Molecular Weight

251.28

Formula

C₁₆H₁₃NO₂

CAS No.

2162962-69-6

SMILES

OC1=CC=C2C(C3=CC=C(O)C(C)=C3)=CC=NC2=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
CU-CPT-9a
Cat. No.:
HY-112667
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CU-CPT-9a

Cat. No.: HY-112667