PAQ
PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells.
For research use only. We do not sell to patients.
- CAS No.: 943902-10-1
- Formula: C14H11N3
- Molecular Weight:221.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Calcium Channel Isoforms
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Neurotoxin MPTP (HY-15608) induced dopamine depletion in Parkinson disease in C57BL/6 mice[1]
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Dosage:25-50 mg/kg
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Administration:p.o. for 11 days
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Result:Reduced levels of striatal DA and DOPAC+HVA/DA ratios. Maintained dendritic network in midbrain tissue sections in TH+ neurons.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 943902-10-1
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Molecular Weight 221.26
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Formula C14H11N3
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SMILES
NC1=CC=C2N=CC(C3=CC=CC=C3)=NC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)