PAQ
PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells.
For research use only. We do not sell to patients.
- CAS No.: 943902-10-1
- Formula: C14H11N3
- Molecular Weight:221.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-113468
3-O-Methyl-DL-DOPAEndogenous Metabolite -
HY-113468R
3-O-Methyl-DL-DOPA (Standard)Endogenous Metabolite -
HY-121252
DopalNeurotoxin -
HY-120251A
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HY-N3126
Orsellinic acidBenzoic Acid Derivative -
HY-W096171
D-DopaGCPII Inhibitor -
HY-125339
Ro 41-0960COMT Inhibitor -
HY-N3126R
Orsellinic acid (Standard)Standard Of Orsellinic Acid -
HY-121252A
Dopal (purity>80%)α-Synuclein Aggregation Inducer -
HY-138185
Collismycin ABacterial Metabolite Xie -
HY-139008
RC363GPx1 Activator
All Calcium Channel Isoforms
More
Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Neurotoxin MPTP (HY-15608) induced dopamine depletion in Parkinson disease in C57BL/6 mice[1]
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Dosage:25-50 mg/kg
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Administration:p.o. for 11 days
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Result:Reduced levels of striatal DA and DOPAC+HVA/DA ratios. Maintained dendritic network in midbrain tissue sections in TH+ neurons.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 943902-10-1
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Molecular Weight 221.26
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Formula C14H11N3
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SMILES
NC1=CC=C2N=CC(C3=CC=CC=C3)=NC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Calcium Spark Assay
Calcium sparks are localized, transient increases in intracellular calcium concentration ([Ca2+]i) that occur in cardiac myocytes and represent elementary events underlying excitation-contraction coupling. These events are generated by the coordinated opening of clusters of ryanodine receptors (RyRs) on the sarcoplasmic reticulum membrane, leading to a brief release of Ca2+ into the cytosol. The detection and analysis of calcium sparks provide insights into the mechanisms of calcium handling and signaling in cardiac cells. Imaging techniques using fluorescent calcium indicators such as Fluo-3 are employed to visualize these subcellular calcium transients with high spatial and temporal resolution. The protocol is based on established methodologies described in primary literature for both experimental measurement and automated analysis of calcium sparks.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAQ Related Classifications
HY-138806 Related Classifications
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