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Cat. No.: HY-119757A

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Tyrphostin AG1433 hydrochloride

Name: Tyrphostin AG1433 hydrochloride
Brand: MedChemExpress
SKU: HY-119757A
Availability: PreOrder

(Synonyms: SU1433 hydrochloride; AG1433 hydrochloride)

Tyrphostin AG 1433 is a specific and potent inhibitor of PDGFR-β and of KDR/Flk-1. Tyrphostin AG 1433 acts as an angiogenesis inhibitor.

For research use only. We do not sell to patients.

CAS No.: 168836-03-1
Formula: C₁₆H₁₅ClN₂O₂
Molecular Weight:302.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Tyrphostin AG1433 hydrochloride Chemical Structure

CAS No.: 168836-03-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

Tyrphostin AG 1433 is a specific and potent inhibitor of PDGFR-β and of KDR/Flk-1. Tyrphostin AG 1433 acts as an angiogenesis inhibitor^[1].

All PDGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BE	IC₅₀	>50 μM Compound: 15; SU1433	Antiangiogenic activity in human BE cells after 24 hrs by MTT assay Antiangiogenic activity in human BE cells after 24 hrs by MTT assay	[PMID: 30502116]
HUVEC	IC₅₀	24.65 μM Compound: 15; SU1433	Antiangiogenic activity in HUVEC after 24 hrs by MTT assay Antiangiogenic activity in HUVEC after 24 hrs by MTT assay	[PMID: 30502116]
U-87MG ATCC	IC₅₀	>50 μM Compound: 15; SU1433	Antiangiogenic activity in human U87cells after 24 hrs by MTT assay Antiangiogenic activity in human U87cells after 24 hrs by MTT assay	[PMID: 30502116]

Chemical Information

CAS No. 168836-03-1
Molecular Weight 302.76
Formula C₁₆H₁₅ClN₂O₂
SMILES

OC1=CC=C(C2=NC3=CC(C)=C(C)C=C3N=C2)C=C1O.[H]Cl
Synonyms

SU1433 hydrochloride; AG1433 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. J Kroll, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem.1997 Dec 19;272(51):32521-7 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Tyrphostin AG1433 hydrochloride

CP-673451

TAK-593

Toceranib

Olaratumab

Vorolanib

SU16f

SU14813

Seralutinib

AG 1295

SU4312

PDGFRα kinase inhibitor 1

Toceranib phosphate

All PDGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Tyrphostin AG1433 hydrochloride

CP-673451

TAK-593

Toceranib

Olaratumab

Vorolanib

SU16f

SU14813

Seralutinib

AG 1295

SU4312

PDGFRα kinase inhibitor 1

Toceranib phosphate

All PDGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Tyrphostin AG1433 hydrochloride Related Classifications

HY-119757A Related Classifications

Bioz