1. Protein Tyrosine Kinase/RTK
  2. PDGFR
    VEGFR
  3. SU4312

SU4312 

Cat. No.: HY-100349 Purity: 98.19%
Handling Instructions

SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively.

For research use only. We do not sell to patients.

SU4312 Chemical Structure

SU4312 Chemical Structure

CAS No. : 5812-07-7

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5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Description

SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1].

IC50 & Target[1]

PDGFR

 

Flk-1

 

In Vitro

Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

264.32

Formula

C₁₇H₁₆N₂O

CAS No.

5812-07-7

SMILES

O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

References
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Keywords:

SU4312SU 4312SU-4312PDGFRVEGFRPlatelet-derived growth factor receptorVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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Product Name:
SU4312
Cat. No.:
HY-100349
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