5812-07-7
5812-07-7
Chemical Structure
SU4312
- CAS No.: 5812-07-7
- Formula:C17H16N2O
- Molecular Weight:264.32
IUPAC Name: (Z)-3-(4-(dimethylamino)benzylidene)indolin-2-one
InChIKey: UAKWLVYMKBWHMX-PTNGSMBKSA-N
SMILES: O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3
Biological Activity: SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SU4312 | 99.74% | SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-100349Acis-SU4312 -
Similarity Score 0.85
HY-21291SU-4313 -
Similarity Score 0.85
HY-21289SU5205 -
Similarity Score 0.85
HY-21290SU-4942 -
Similarity Score 0.77
HY-21293SU5201 -
Similarity Score 0.76
HY-21292SU5214 -
Similarity Score 0.74
HY-126319SU5204 -
Similarity Score 0.74
HY-124330Tripolin A -
Similarity Score 0.73
HY-148316hVEGF-IN-2 -
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