1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. VEGFR
    EGFR
  3. SU5204

SU5204 

Cat. No.: HY-126319 Purity: 98.89%
Handling Instructions

SU5204, a tyrosine kinase inhibitor extracted from patent US5792783A, has IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively.

For research use only. We do not sell to patients.

SU5204 Chemical Structure

SU5204 Chemical Structure

CAS No. : 186611-11-0

Size Price Stock Quantity
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 380 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SU5204, a tyrosine kinase inhibitor extracted from patent US5792783A, has IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively[1].

IC50 & Target[1]

VEGFR2

4 μM (IC50)

HER2

51.5 μM (IC50)

Molecular Weight

265.31

Formula

C₁₇H₁₅NO₂

CAS No.

186611-11-0

SMILES

O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=CC=C3OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (376.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7692 mL 18.8459 mL 37.6918 mL
5 mM 0.7538 mL 3.7692 mL 7.5384 mL
10 mM 0.3769 mL 1.8846 mL 3.7692 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SU5204SU 5204SU-5204VEGFREGFRVascular endothelial growth factor receptorEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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Product Name:
SU5204
Cat. No.:
HY-126319
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