hVEGF-IN-2
hVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific agents.
For research use only. We do not sell to patients.
- CAS No.: 186610-88-8
- Formula: C19H18N2O2
- Molecular Weight:306.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
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Biological Activity
Description
IC50 & Target
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VEGFR1 2.5 μM (IC50) |
PDGF 33.1 μM (IC50) |
In Vitro
hVEGF-IN-2 (0-100 μM) shows the inhibitory activities to particular RTKs at the cellular level with IC50 values of 2.5, 33.1, >100, >100 and >100 nM for VEGF, PDGF, EGF, HER-2 and IGF-1, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 186610-88-8
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Molecular Weight 306.36
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Formula C19H18N2O2
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SMILES
O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N4CCOCC4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)