1. Protein Tyrosine Kinase/RTK
  2. PDGFR

PDGFRα kinase inhibitor 1 

Cat. No.: HY-111507
Handling Instructions

PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively.

For research use only. We do not sell to patients.

PDGFRα kinase inhibitor 1 Chemical Structure

PDGFRα kinase inhibitor 1 Chemical Structure

CAS No. : 2209053-93-8

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  • Biological Activity

  • Technical Information

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  • References

Description

PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].

IC50 & Target[1]

PDGFRα

132 nM (IC50)

PDGFRβ

6115 nM (IC50)

In Vitro

PDGFRα kinase inhibitor 1 (CHMFL-PDGFR-159, Compound 15i) exhibits weak inhibition to DDR1 kinase (IC50: 2462±126 nM)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7045 mL 8.5224 mL 17.0448 mL
5 mM 0.3409 mL 1.7045 mL 3.4090 mL
10 mM 0.1704 mL 0.8522 mL 1.7045 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

586.69

Formula

C₃₄H₃₄N₈O₂

CAS No.

2209053-93-8

SMILES

CC(C=CC(NC(C1=CC=C(CN(CCN(C)C)C(C2=CC=CN=C2)=O)C=C1)=O)=C3)=C3NC4=NC=CC(C5=CC=CN=C5)=N4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
PDGFRα kinase inhibitor 1
Cat. No.:
HY-111507
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PDGFRα kinase inhibitor 1

Cat. No.: HY-111507