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  3. PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1 

Cat. No.: HY-111507 Purity: 99.90%
Handling Instructions

PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively.

For research use only. We do not sell to patients.

PDGFRα kinase inhibitor 1 Chemical Structure

PDGFRα kinase inhibitor 1 Chemical Structure

CAS No. : 2209053-93-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 452 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].

IC50 & Target[1]

PDGFRα

132 nM (IC50)

PDGFRβ

6115 nM (IC50)

In Vitro

PDGFRα kinase inhibitor 1 (CHMFL-PDGFR-159, Compound 15i) exhibits weak inhibition to DDR1 kinase (IC50: 2462±126 nM)[1].

Molecular Weight

586.69

Formula

C₃₄H₃₄N₈O₂

CAS No.

2209053-93-8

SMILES

CC(C=CC(NC(C1=CC=C(CN(CCN(C)C)C(C2=CC=CN=C2)=O)C=C1)=O)=C3)=C3NC4=NC=CC(C5=CC=CN=C5)=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 260 mg/mL (443.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7045 mL 8.5224 mL 17.0448 mL
5 mM 0.3409 mL 1.7045 mL 3.4090 mL
10 mM 0.1704 mL 0.8522 mL 1.7045 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (3.70 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (3.70 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (3.70 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

PDGFRα kinase inhibitor 1PDGFRα kinase inhibitor1PDGFRα kinase inhibitor-1PDGFRPlatelet-derived growth factor receptorInhibitorinhibitorinhibit

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Product name:
PDGFRα kinase inhibitor 1
Cat. No.:
HY-111507
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