1. Protein Tyrosine Kinase/RTK
  2. VEGFR
    PDGFR
  3. Vorolanib

Vorolanib (Synonyms: CM082; X-82)

Cat. No.: HY-109019 Purity: 99.80%
Handling Instructions

Vorolanib (CM082; X-82) is an orally active, multikinase VEGFR/PDGFR inhibitor. Vorolanib minimizes toxicity, disrupts tumor angiogenesis and tumor cell proliferation, and induces of tumor cell death.

For research use only. We do not sell to patients.

Vorolanib Chemical Structure

Vorolanib Chemical Structure

CAS No. : 1013920-15-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Vorolanib (CM082; X-82) is an orally active, multikinase VEGFR/PDGFR inhibitor. Vorolanib minimizes toxicity, disrupts tumor angiogenesis and tumor cell proliferation, and induces of tumor cell death[1].

IC50 & Target

VEGFR, PDGFR[1]

Molecular Weight

439.48

Formula

C₂₃H₂₆FN₅O₃

CAS No.

1013920-15-4

SMILES

O=C1/C(C2=CC(F)=CC=C2N1)=C/C(NC(C)=C3C(N[[email protected]@H]4CN(C(N(C)C)=O)CC4)=O)=C3C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 27 mg/mL (61.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2754 mL 11.3771 mL 22.7542 mL
5 mM 0.4551 mL 2.2754 mL 4.5508 mL
10 mM 0.2275 mL 1.1377 mL 2.2754 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (5.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

VorolanibCM082X-82CM 082CM-082X82X 82VEGFRPDGFRVascular endothelial growth factor receptorPlatelet-derived growth factor receptorInhibitorinhibitorinhibit

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Vorolanib
Cat. No.:
HY-109019
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