1. Cell Cycle/DNA Damage
    Apoptosis
  2. Topoisomerase
    Apoptosis
  3. CS1

CS1 

Cat. No.: HY-137005
Handling Instructions

CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis.

For research use only. We do not sell to patients.

CS1 Chemical Structure

CS1 Chemical Structure

CAS No. : 1448009-94-6

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Description

CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis[1].

IC50 & Target

topoisomerase II alpha

 

In Vitro

CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 µM for MCF-7 and MCF7/ADR cells, respectively[1]
. CS1 (10, 50, 100 µM) inhibits the activity of topoisomerase II α (Topo IIα)[1].
CS1 (0-20 µM) shows antiproliferation activity in cancer cells[1].
CS1 (2.5, 5, 10 µM) induces cell cycle arrest at the G2/M phase[1].
CS1 (2.5, 5, 10 µM) induces cell apoptosis[1].
CS1 (5, 10, 15 µM; 24 h) induces DNA breaks in MDA-MB-231 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10 µM
Incubation Time:
Result: Cells were arrest at the G2/M phase.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10 µM
Incubation Time:
Result: Induced apoptosis
In Vivo

CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old female athymic nude mice (BALB/c-nu)[1]
Dosage: 20 mg/kg
Administration: i.v., every other day for two weeks
Result: Showed antitumor effects.
Molecular Weight

252.26

Formula

C16H12O3

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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CS1
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HY-137005
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