2. Cytoskeleton Metabolic Enzyme/Protease
  3. Dynamin HIV Integrase
  4. Bis-T-23

Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD).

For research use only. We do not sell to patients.

Bis-T-23 Chemical Structure

Bis-T-23 Chemical Structure

CAS No. : 171674-76-3

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Based on 1 publication(s) in Google Scholar

Bis-T-23 Related Antibodies

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Description

Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD)[1][2].

In Vitro

Bis-T-23 (AG1717) (0.18 μM) can inhibit HIV-1 integrase[2].
AG1717 (2 μM) can inhibit binding of integrase to the substrate DNA[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-T-23 Related Antibodies
In Vivo

Bis-T-23 (AG1717) (1 ng) targets actin-dependent dynamin oligomerization in podocytes to promote proper GFB function[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorate proteinuria by altering actin dynamics[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorates or prevented proteinuria and diminished mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (8 weeks old, males); Mice[1]
Dosage: 20, 40 mg/kg; 40 mg/kg
Administration: Intraperitoneal injection; signle, once for 6 consecutive days
Result: Specifically reduced proteinuria on days 18 and 24.
Caused a transient reduction of proteinuria (single dose) in PKCε KO mice.
Completely prevented the onset of high-level proteinuria in the CD2AP KO mice.
Significantly extended the lifespans of CD2AP KO mice.
Led to improved glomerular histology with less mesangial matrix accumulation.
Animal Model: Zebrafish[1]
Dosage: 1 ng
Administration: Injection
Result: Promoted oligomerization of zebrafish Dyn2.
Increased the number of focal adhesions (FAs) and stress fibers in cultured podocytes.
Molecular Weight

480.43

Formula

C23H20N4O8
CAS No.
SMILES

O=C(/C(C#N)=C/C1=CC(O)=C(C(O)=C1)O)NCCCNC(/C(C#N)=C/C2=CC(O)=C(C(O)=C2)O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bis-T-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-T-23171674-76-3AG1717AG 1717AG-1717DynaminHIV Integrasechronic kidney diseases (CKD)proteinuriaglomerular filtration barrier (GFB)dynaminactin cytoskeletonHIV integraseInhibitorinhibitorinhibit

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