1. Protein Tyrosine Kinase/RTK
  2. PDGFR
  3. AG 370

AG 370 

Cat. No.: HY-116111
Handling Instructions

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor.

For research use only. We do not sell to patients.

AG 370 Chemical Structure

AG 370 Chemical Structure

CAS No. : 134036-53-6

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Description

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].

IC50 & Target[1]

PDGFR

20 μM (IC50)

In Vitro

AG 370 blocks mitogenesis induced by epidermal growth factor (IC50 of 50 μM) and human serum (IC50 of 50 μM)[1][1].
In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor[1][1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

259.27

Formula

C15H9N5

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
AG 370
Cat. No.:
HY-116111
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