2. Protein Tyrosine Kinase/RTK
  3. PDGFR
  4. AG 370

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor.

For research use only. We do not sell to patients.

AG 370 Chemical Structure

AG 370 Chemical Structure

CAS No. : 134036-53-6

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Based on 1 publication(s) in Google Scholar

AG 370 Related Antibodies

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Description

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].

IC50 & Target[1]

PDGFR

20 μM (IC50)

In Vitro

AG 370 blocks mitogenesis induced by epidermal growth factor (IC50 of 50 μM) and human serum (IC50 of 50 μM)[1][1].
In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor[1][1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AG 370 Related Antibodies
Molecular Weight

259.27

Formula

C15H9N5
CAS No.
SMILES

N#C/C(C#N)=C(N)/C(C#N)=C\C1=CC=C(NC=C2)C2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AG 370 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG 370134036-53-6AG370AG-370PDGFRPlatelet-derived growth factor receptormitogenesisautophosphorylationtyrosine phosphorylationInhibitorinhibitorinhibit

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HY-116111
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