1. Protein Tyrosine Kinase/RTK
  2. PDGFR
  3. JNJ-​10198409

JNJ-​10198409 

Cat. No.: HY-W011266 Purity: >99.0%
Handling Instructions

JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM).

For research use only. We do not sell to patients.

JNJ-​10198409 Chemical Structure

JNJ-​10198409 Chemical Structure

CAS No. : 627518-40-5

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Estimated Time of Arrival: December 31
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Description

JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM)[1][2].

IC50 & Target[2]

PDGFRβ

4.2 nM (IC50)

PDGFRα

45 nM (IC50)

In Vitro

JNJ-10198409 has potent antiproliferative activity in six of eight human tumor cell lines (IC50<0.033 μM) and is a potent inhibitor of the c-Abl kinase (IC50=22 nM)[1][2].

Molecular Weight

325.34

Formula

C₁₈H₁₆FN₃O₂

CAS No.

627518-40-5

SMILES

COC1=CC2=C(C=C1OC)CC3=C2NN=C3NC4=CC=CC(F)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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KeyWords:

JNJ-​10198409 | PDGFR | Platelet-derived growth factor receptor | Inhibitor | inhibitor | inhibit

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JNJ-​10198409
Cat. No.:
HY-W011266
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