(Z)-Tyrphostin A51
(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation.
For research use only. We do not sell to patients.
- CAS No.: 122520-90-5
- Formula: C13H8N4O3
- Molecular Weight:268.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
8 × 10-1μM
Compound: 120
|
Inhibition of EGFR in human A431 cells
Inhibition of EGFR in human A431 cells
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[PMID: 1479375] |
Chemical Information
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CAS No. 122520-90-5
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Molecular Weight 268.23
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Formula C13H8N4O3
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SMILES
N#C/C(C#N)=C(N)/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1.[(Z)]
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Synonyms
(Z)-AG-183
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 20 mg/mL (74.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7281 mL | 18.6407 mL | 37.2814 mL | 93.2036 mL |
| 5 mM | 0.7456 mL | 3.7281 mL | 7.4563 mL | 18.6407 mL | |
| 10 mM | 0.3728 mL | 1.8641 mL | 3.7281 mL | 9.3204 mL | |
| 15 mM | 0.2485 mL | 1.2427 mL | 2.4854 mL | 6.2136 mL | |
| 20 mM | 0.1864 mL | 0.9320 mL | 1.8641 mL | 4.6602 mL | |
| 25 mM | 0.1491 mL | 0.7456 mL | 1.4913 mL | 3.7281 mL | |
| 30 mM | 0.1243 mL | 0.6214 mL | 1.2427 mL | 3.1068 mL | |
| 40 mM | 0.0932 mL | 0.4660 mL | 0.9320 mL | 2.3301 mL | |
| 50 mM | 0.0746 mL | 0.3728 mL | 0.7456 mL | 1.8641 mL | |
| 60 mM | 0.0621 mL | 0.3107 mL | 0.6214 mL | 1.5534 mL |
(Z)-Tyrphostin A51 Related Classifications
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